The series follows a former New York police detective named Carrie Wells, who has hyperthymesia, a rare medical condition that gives her the ability to remember everything. She is reluctantly asked by her former boyfriend and one-time partner to join his homicide unit after he asks for help with solving a case. The move allows her to do the one thing she has been trying to remember, that of finding out how her sister was murdered.

Cast:
Poppy Montgomery as Carrie Wells
Dylan Walsh as Al Burns
Kevin Rankin as Roe Sanders
Michael Gaston as Mike Costello
Daya Vaidya as Nina Inara
Deanna Dunagan as Alex
Samira Wiley as Gina
Kyle Beltran as Henry
Madison Arnold as Mr. Wanamaker
Haley Murphy as Rachel
Victoria Leigh as young Carrie